Effect of glycemic status on myocardial deformation and microvascular function in uncomplicated pediatric type 1 diabetes mellitus: cardiac magnetic resonance imaging

Table 2 CMR characteristics compared among type 1 diabetics and controls

	Controls	T1DM		p
	Controls	HbA1c < 7.0%	HbA1c ≥ 7.0%	p
Left ventricular geometry
LVEDVi, ml/m²	74.0 ± 8.1	80.9 ± 10.4	73.0 ± 10.5	0.822
LVESVi, ml/m²	28.2 ± 3.4	31.5 ± 6.1	29.0 ± 5.2	0841
LVEF, %	61.6 ± 4.4	61.5 ± 3.1	61.0 ± 3.9	0.335
LVMi, g/m²	37.9 ± 5.8	44.9 ± 7.9	38.9 ± 9.4	0.644
LVRI	0.5 ± 0.1	0.5 ± 0.1	0.5 ± 0.1	0.343
Myocardial strain
Radial peak strain, %	36.8 ± 8.4	45.2 ± 4.6*	43.9 ± 11.9*	0.009
Circumferential peak strain, %	− 21.6 ± 3.1	− 23.2 ± 1.9	− 21.6 ± 2.5	0.521
Longitudinal peak strain, %	− 13.4 ± 2.8	− 15.1 ± 3.7*	− 15.1 ± 2.9*	0.002
Radial PSSR, 1/s	3.4 ± 0.9	2.8 ± 0.8	2.9 ± 0.9	0.122
Circumferential PSSR, 1/s	− 1.5 ± 0.3	− 1.3 ± 0.2	− 1.3 ± 0.3	0.077
Longitudinal PSSR, 1/s	− 1.3 ± 0.6	− 1.0 ± 0.3	− 1.0 ± 0.3	0.181
Radial PDSR, 1/s	− 3.4 ± 0.4	− 3.5 ± 0.9	− 3.2 ± 1.2	0.092
Circumferential PDSR, 1/s	1.5 ± 0.4	1.4 ± 0.4	1.3 ± 0.3*	0.021
Longitudinal PDSR, 1/s	1.5 ± 0.5	1.2 ± 0.2*	1.0 ± 0.2*^&	< 0.001
Myocardial perfusion function
Upslope, %	4.2 ± 1.4	4.3 ± 1.1	3.1 ± 0.8*^&	< 0.001
TTM, s	30.3 ± 8.4	26.5 ± 8.2	33.7 ± 10.1	0.242
Max SI	39.1 ± 10.9	37.1 ± 8.9	32.7 ± 8.9*	0.029
Perfusion index	0.1 ± 0.02	0.1 ± 0.01	0.1 ± 0.01	0.430

HbA1c hemoglobin A1c, LVEDVi indexed left ventricular end-diastolic volume, LVESVi indexed left ventricular end-systolic volume, LVEF left ventricular ejection fraction, LVRI left ventricular remodeling index, LVMi indexed left ventricular mass, PSSR peak systolic strain rate, PDSR peak diastolic strain rate, TTM time to maximal signal intensity, Max SI maximal signal intensity. *p < 0.05 compared to controls, ^&p < 0.05 compared to patients with HbA1c < 7.0%

ISSN: 1475-2840