Table 2 Parameters of glucose variability in patients taking vildagliptin (100 mg daily) or sitagliptin (50 mg daily)
Vildagliptin | Sitagliptin | P-value | |
|---|---|---|---|
24-h mean glucose level (mg/dL) | 142.1 ± 14.0 | 153.2 ± 29.7 | 0.012* |
0:00 to 08:00 (night) mean glucose level (mg/dL) | 117.4 ± 22.1 | 130.9 ± 26.3 | 0.042* |
08:00 to 24:00 (day) mean glucose level (mg/dL) | 154.1 ± 25.6 | 164.4 ± 35.3 | 0.043* |
SD over 24 h (mg/dL) | 35.5 ± 12.6 | 37.0 ± 13.9 | 0.542 |
Preprandial glucose level (mg/dL) | 110.5 ± 33.5 | 129.4 ± 45.1 | 0.040* |
Preprandial glucose level (mg/dL) | 128.1 ± 16.2 | 133.5 ± 26.8 | 0.282 |
lunch | 109.1 ± 22.2 | 120.9 ± 44.8 | 0.165 |
Highest postprandial glucose level within 3 hours after each meal (mg/dL) | 112.4 ± 21.1 | 116.6 ± 24.7 | 0.221 |
Highest postprandial glucose level within 3 hours after each meal (mg/dL) | 211.0 ± 40.0 | 228.0 ± 58.4 | 0.117 |
lunch | 188.6 ±37.7 | 203.1 ± 50.3 | 0.172 |
supper | 206.1 ± 40.2 | 223.2 ± 43.5 | 0.015* |
Time from start of meal to the highest postprandial glucose level (minutes) | |||
breakfast | 76.0 ± 18.0 | 86.0 ± 28.4 | 0.204 |
lunch | 93.3 ± 30.2 | 99.0 ± 35.6 | 0.579 |
supper | 81.8 ± 24.6 | 93.0 ± 26.4 | 0.223 |
Differences between preprandial and highest postprandial glucose level for each meal (mg/dL) | |||
breakfast | 83.0 ± 37.1 | 94.5 ± 46.3 | 0.185 |
lunch | 79.5 ± 31.8 | 82.3 ± 33.9 | 0.774 |
supper | 93.7 ± 35.7 | 106.6 ± 43.2 | 0.065 |
AUC (≧180 mg/dL) for glycemic variability within 3 h of each meal (mg·min/dL) | |||
breakfast | 484.3 ± 541.1 | 897.9 ± 1097 | 0.025* |
lunch | 306.0 ± 554.8 | 630.5 ± 1017.2 | 0.152 |
supper | 523.5 ± 618.3 | 703.4 ± 676.4 | 0.106 |
AOC (<70 mg·/dL) for glycemic variability in 24 h (mg·min/dL) | |||
95.6 ± 243.0 | 16.2 ± 61.2 | 0.183 |